Chronic T-type Ca2+ channel blockade with mibefradil in hyperinsulinemic, insulin-resistant and hypertensive rats
S Verma, S Bhanot, A Hicke… - Cardiovascular …, 1997 - academic.oup.com
… study is the first report of long-term administration of a T-type calcium channel blocker in
hyperinsulinemic, insulin-resistant and hypertensive rats. Chronic mibefradil treatment of FH rats …
hyperinsulinemic, insulin-resistant and hypertensive rats. Chronic mibefradil treatment of FH rats …
T-type but not L-type calcium channels mediate vasoconstrictor responses in rat mesenteric arterioles in vivo
F Gustafsson, M Salomonsson, BL Jensen… - … of Hypertension, 2000 - journals.lww.com
… the relatively selective Ttype calcium antagonist mibefradil (10 p#… with severe and malignant
arterial hypertension were … points during a hyperinsulinemic isoglycemic glucose clamp and …
arterial hypertension were … points during a hyperinsulinemic isoglycemic glucose clamp and …
Towards selective antagonists of T‐type calcium channels: design, characterization and potential applications of NNC 55‐0396
M Li, JB Hansen, L Huang, BM Keyser… - Cardiovascular drug …, 2005 - Wiley Online Library
… and reducing hyperinsulinemia (116). It has been demonstrated that … Chronic T-type Ca2+
channel blockade with mibefradil in hyperinsulinemic, insulin-resistant and hypertensive rats…
channel blockade with mibefradil in hyperinsulinemic, insulin-resistant and hypertensive rats…
A mibefradil metabolite is a potent intracellular blocker of L-type Ca2+ currents in pancreatic β-cells
S Wu, M Zhang, PA Vest, A Bhattacharjee, L Liu… - Journal of Pharmacology …, 2000 - ASPET
… nM, mibefradil exhibited no long-term effect on the T-type Ca … whether mibefradil or dm-mibefradil
inhibits L- or T-type Ca 2… hyperinsulinemia (Verma et al., 1997). Our results show that …
inhibits L- or T-type Ca 2… hyperinsulinemia (Verma et al., 1997). Our results show that …
Corrigendum to Chronic T-type calcium channel blockade with mibefradil in hyperinsulinemic, insulin-resistant and hypertensive rats (Cardiovasc res 1997; 34: 121 …
S Verma, S Bhanot, A Hicke… - Cardiovascular …, 1998 - scholar.archive.org
… Table 2 General characteristics of rats in the 4 experimental groups in the reversal study …
Fructose hypertensive rats (8 weeks fructose-fed) and their age and weight matched control …
Fructose hypertensive rats (8 weeks fructose-fed) and their age and weight matched control …
Mechanisms of hypertension in hyperinsulinemic and insulin resistant fructose hypertensive rats
S Verma - 1996 - open.library.ubc.ca
… rats, we studied the effects of mibefradil (a calcium channel … examined the chronic effects of
a calcium antagonist (mibefradil) … blocks the T-type calcium channels. Although the available …
a calcium antagonist (mibefradil) … blocks the T-type calcium channels. Although the available …
[HTML][HTML] Mibefradil reduces blood glucose concentration in db/db mice
Y Lu, M Long, S Zhou, Z Xu, F Hu, M Li - Clinics, 2014 - SciELO Brasil
… to mibefradil but more selective for T-type Ca 2+ channels, but … may play a role in the
pathogenesis of hyperinsulinemia in … The hallmark of diabetes mellitus is chronically high fasting …
pathogenesis of hyperinsulinemia in … The hallmark of diabetes mellitus is chronically high fasting …
Role of T-Type Ca2+ Channels in Basal Insulin Release
M Li - T-type Calcium Channels in Basic and Clinical Science, 2014 - Springer
… Long-term treatment with the T-type Ca 2+ channel blocker, mibefradil, both prevented and
reversed the development of hyperinsulinemia in an insulin-resistant and hypertensive rat …
reversed the development of hyperinsulinemia in an insulin-resistant and hypertensive rat …
Mibefradil prevents L-NAME-exacerbated nephrosclerosis in spontaneously hypertensive rats
C Qiu, P Bruneval, A Roeckel, D Heudes… - … of hypertension, 1999 - journals.lww.com
… In this study we compared the long-term effects of mibefradil with those of cilazapril, an ACE
… the T-type calcium channel blocker mibefradil prevents the development of hypertension, …
… the T-type calcium channel blocker mibefradil prevents the development of hypertension, …
Mibefradil Alleviates High-Glucose–Induced Cardiac Hypertrophy by Inhibiting PI3K/Akt/MTOR-Mediated Autophagy
LG Zhao, PL Li, Y Dai, JL Deng, MY Shan… - Journal of …, 2020 - journals.lww.com
… Mibefradil, which acts as a T-type calcium channel blocker, … the effects and mechanism
of mibefradil on high-glucose–… rate, reduces hyperglycemia and hyperinsulinemia, and has …
of mibefradil on high-glucose–… rate, reduces hyperglycemia and hyperinsulinemia, and has …